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Firdapse (amifampridine) has been approved in Japan to treat people with Lambert-Eaton myasthenic syndrome (LEMS). The therapy will be supplied in the form of oral tablets containing 10 mg of amifampridine, according to Catalyst Pharmaceuticals, the company that holds Firdapse’s licensing rights in North America. In collaboration with…

Firdapse (amifampridine) can help ease symptoms of Lambert-Eaton myasthenic syndrome (LEMS) in patients who don’t have an underlying cancer and its efficacy is consistent regardless of how long a delay there is before it’s started. That’s according to a study, “Safety, efficacy and steroid-sparing…

Lambert‐Eaton myasthenic syndrome (LEMS) may, in rare cases, manifest with severe respiratory muscle weakness leading to respiratory failure, researchers noted in a case study. “Establishing the association of LEMS with respiratory disease could lead to timely identification of LEMS, diagnosis of an underlying malignancy (if unknown), and initiation of…

People with Lambert-Eaton myasthenic syndrome (LEMS) have a lower quality of life and a higher disease burden than do those with myasthenia gravis (MG) or adults in the general population, according to a survey-based study in Germany. “Quality of life reflects one aspect of the burden of disease.

The U.S. Food and Drug Administration (FDA) has approved increasing from 80 to 100 mg the maximum recommended daily dose of Firdapse (amifampridine) for adults and children weighing at least 45 kg (about 99 pounds) with Lambert-Eaton myasthenic syndrome (LEMS). The decision follows a supplemental new drug application…

A man in his 60s who developed Lambert-Eaton myasthenic syndrome (LEMS) secondary to prostate cancer saw his neurological symptoms ease after receiving treatment with amifampridine — the active ingredient in the approved LEMS therapy Firdapse. That’s according to a report detailing the man’s case, unusual, per the researchers,…

The inaugural Lambert-Eaton myasthenic syndrome (LEMS) Awareness Day — which will be held each year on March 30 to call attention to the rare autoimmune disorder — was “fantastic,” according to the nonprofit association that created the event. “We appreciate everything everyone did for this first LEMS Awareness Day,…

The lack of a reflex response that was relieved temporarily after exercise, a phenomenon known as post-exercise facilitation, is an early sign of Lambert-Eaton myasthenic syndrome (LEMS), a case report suggests. The report described the case of a woman, 62, who had a neuroendocrine tumor in the gallbladder…

The rare case of a man with lung cancer complicated by two co-occurring cancer-associated syndromes — Lambert-Eaton myasthenic syndrome (LEMS) and syndrome of inappropriate antidiuretic hormone secretion (SIADH) — was described in a recent report. According to its scientists, only four other documented reports of LEMS and SIADH developing…

DyDo Pharma is seeking approval of Firdapse (amifampridine) to treat Lambert-Eaton myasthenic syndrome (LEMS) in Japan. A decision from Japan’s Pharmaceuticals and Medical Devices Agency is expected in September. DyDo’s application was submitted in collaboration with Catalyst Pharmaceuticals, which developed Firdapse. DyDo is leading the development…