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An antibody test specifically for paraneoplastic LEMS?
Good morning my fellow LEMons!
Did you know that studies have been performed to study Anti-SOX1 (Anti-Sry-like high mobility group box 1) antibodies and found that having them present is predictive of paraneoplastic LEMS?
What does this mean?
We can test for Anti-SOX1 antibodies in patients that may not test positive for N-type or P/Q calcium channel antibodies to determine if they have LEMS. We can also test patients with P/Q or N-type antibodies to get a better idea of if there LEMS is caused by cancer. Positive Anti-SOX1 antibodies are “highly suggestive” of paraneoplastic LEMS.
If you want to read more about this, you can check out the article posted on Lambert-Eaton News or you can check out the actual study here.
Have any of you been tested for Anti-SOX1 antibodies?
What do you think about this?
Do you think that in the future this antibody test could be offered every 6 months to a year for those patients still undergoing cancer surveillance? Do you think it could replace a PET or CT scan?
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