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The Case For Time Release Firdapse
This is exciting news that Catalyst Pharmaceuticals is working towards a time release version of Firdapse, the only FDA approved drug for adults with LEMS. Currently it’s only available as 10 MG tablets, with most patients dosing at 2 to 4 hour intervals. In my case I take my dose every 4 hours. That’s quite a schedule when you consider how busy a daily routine can be! And occasionally I am late with a dose and have to slide doses the remainder of the day. Oh, and my last dose is usually around 8 PM, so my Firdapse coverage tapers off somewhere around midnight, until the next morning dose. Time release Firdapse could be a game changer, making 24 hour coverage possible. As it is now, I’ve had overnight LEMS issues, so I take one 180 MG time release Mestinon for overnight coverage. It helps.
I’m anxious to hear when Catalyst begins their trials for this new version. Maybe I can give it a go!
What’s your case for a time release Firdapse schedule? -
3 Replies
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I think that would be amazing! Grace has extreme weakness in the morning because her last dose of rizurgi is at 6pm the night before. A time release pill would be a game changer!!!
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@lorildunham I agree! I just spoke with someone at Catalyst about when when some patients may be able to start trials with a formulation, but no word back yet. I don’t know Grace’s treatment plan, but I do take a 180 MG Mestinon to give me some coverage overnight.
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This is a great step in the right direction. Grace does not take the time release mestinon yet but I’d like to ask about it at her next neurology appt. I hope it could help her a bit throughout the night and first thing in the am.
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